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KMID : 0358619920260010045
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Korean Journal of Physiology
1992 Volume.26 No. 1 p.45 ~ p.54
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Effects of pH, , and Adenosine on the Contractility of Pig Coronary Artery
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Chang Seok-Jong
Kim Il-Seon
Jeon Byeong-Hwa
Kim Se-Hoon
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Abstract
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Effects of pH, , and adenosine on the vascular contractility were investigated in the pig coronary arteries. The helical strips of isolated coronary arteries were immersed in the HEPES or -buffered Tyrode’s solution equilibrated with 100% . The contraction was recorded isometrically using a force transducer. The amplitudes of contraction induced by ACh, high , and electrical Held stimulation (EFS) were decreased by elevating extracellular pH (pHo) and were increased by lowering pHo. A shift from at constant pHo (pH 7.4) reduced the contractions induced by ACh, high , EFS. However the contraction induced by 100mM was less influenced by the change of pHo or . The contraction induced by ACh in free Tyrode’s solution as well as the contraction developed by the addition of extracellular of were decreased by lowering pHo and were increased by elevating pHo. High (25mM) induced contraction at pH 6.8 was not returned to the level of the contraction at pH 7.4 by the elevation of extracellular. calcium . Adenosine-induced relaxation was more significant with 5% than 0% in the high -induced contraction and was more significant with low pHo than high pHo in the contraction induced by EFS. From the above results, it is suggested that and inhibit influx as well as release from intracellular storage sites and enhance the relaxing effect of adenosine in the pig coronary artery.
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KEYWORD
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pH, Adenosine, Pig coronary artery
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